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[18F]AlF-NOTA-DV1-k-(DV3)
- Development stage
- Preclinical
- Lead developer
- KU Leuven
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
`[18F]AlF-NOTA-DV1-k-(DV3)` is a fluorine-18-labeled radiopharmaceutical developed by KU Leuven for positron emission tomography (PET) imaging of C-X-C chemokine receptor type 4 (CXCR4). The tracer is based on a D-amino acid-based peptide scaffold (DV1-k-(DV3)) derived from viral macrophage inflammatory protein II (vMIP-II), which is conjugated to a NOTA chelator and labeled with aluminum fluoride-18 ([18F]AlF). It exhibits high binding affinity to both human and murine CXCR4, making it a valuable tool for translational molecular imaging in oncology, cardiology, and inflammatory or infectious diseases where CXCR4 is upregulated.
- Other names
- 18F-AlF-NOTA-DV1-k-(DV3)AlF-NOTA-DV1-k-(DV3)[18F]AlF-NOTA-DV1-k-DV3
02
Targets
CXCR4 (C-X-C motif chemokine receptor 4)
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